Pair Name	Allicin, Fluorouracil
Disease Info	[ICD-11: 2C12]	Hepatocellular carcinoma		Investigative
Biological Phenomena	Induction-->ROS-mediated mitochondrial pathway
Gene Regulation	Down-regulation	Expression	BCL2	hsa596
	Up-regulation	Cleavage	CASP3	hsa836
	Up-regulation	Cleavage	PARP1	hsa142
	Up-regulation	Expression	ROS1	hsa6098
In Vitro Model	SK-HEP-1	Liver and intrahepatic bile duct epithelial neoplasm	Homo sapiens (Human)	CVCL_0525
	BEL-7402	Human papillomavirus-related cervical adenocarcinoma	Homo sapiens (Human)	CVCL_5492
In Vivo Model	Male athymic nude mice (4-6-week) were injected subcutaneously into left flank with 1×10⁷ GFP-SK-Hep-1 cells.
Result	Allicin sensitizes hepatocellular cancer cells to anti-tumor activity of 5-fluorouracil through ROS-mediated mitochondrial pathway

Pair Name	Allicin, Fluorouracil
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Biological Phenomena	Induction-->Apoptosis
Gene Regulation	Down-regulation	Expression	ABCB1	hsa5243
	Down-regulation	Expression	ABCB1	hsa5243
	Down-regulation	Expression	CD44	hsa960
	Down-regulation	Expression	DKK1	hsa22943
	Down-regulation	Expression	WNT5A	hsa7474
In Vitro Model	MKN45	Gastric adenocarcinoma	Homo sapiens (Human)	CVCL_0434
Result	Our findings indicate that the combination of allicin with 5-FU could reverse multidrug resistance in the GC cells by reducing the expression of WNT5A, DKK1, MDR1, P-gp, and CD44 levels.